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Glial and neuronal markers in cerebrospinal fluid predict progression in multiple sclerosis.

Journal article
Authors M Alba Mañé Martínez
Bob Olsson
Laura Bau
Elisabet Matas
Álvaro Cobo Calvo
Ulf Andreasson
Kaj Blennow
Lucia Romero-Pinel
Sergio Martínez-Yélamos
Henrik Zetterberg
Published in Multiple sclerosis (Houndmills, Basingstoke, England)
Volume 21
Issue 5
Pages 550-61
ISSN 1477-0970
Publication year 2015
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 550-61
Language en
Links dx.doi.org/10.1177/1352458514549397
Keywords Biomarkers; cerebrospinal fluid; chitinase 3-like 1 protein; diagnostics; disability progression; glial fibrillary acidic protein; multiple sclerosis; neurofilament light protein; prognostic markers
Subject categories Neurochemistry

Abstract

To investigate glial and neuronal biomarkers in cerebrospinal fluid (CSF) samples from patients with relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS), and to evaluate their ability to predict conversion from CIS to clinically definite MS (CDMS) and also disability progression in MS.

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