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Monocyte and microglial activation in patients with mood-stabilized bipolar disorder.

Journal article
Authors Joel Jakobsson
Maria Bjerke
Sara Sahebi
Anniella Isgren
Carl Johan Ekman
Carl Sellgren
Bob Olsson
Henrik Zetterberg
Kaj Blennow
Erik Pålsson
Mikael Landén
Published in Journal of psychiatry & neuroscience : JPN
Volume 40
Issue 2
Pages 140183
ISSN 1488-2434
Publication year 2015
Published at Institute of Neuroscience and Physiology
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 140183
Language en
Links dx.doi.org/10.1503/jpn.140183
Subject categories Neurochemistry

Abstract

Bipolar disorder is associated with medical comorbidities that have been linked to systemic inflammatory mechanisms. There is, however, limited evidence supporting a role of neuroinflammation in bipolar disorder. Here we tested whether microglial activation and associated tissue remodelling processes are related to bipolar disorder by analyzing markers in cerebrospinal fluid (CSF) and serum from patients and healthy controls.

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