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Swedish Experiences From Patch Testing Methylisothiazolinone Separately.

Journal article
Authors Malin Engfeldt
Johanna Bråred Christensson
Marléne Isaksson
Mihaly Matura
Kristina Ryberg
Berndt Stenberg
Cecilia Svedman
Magnus Bruze
Published in Acta dermato-venereologica
Volume 95
Issue 6
Pages 717-719
ISSN 1651-2057
Publication year 2015
Published at Institute of Clinical Sciences, Department of Dermatology and Venereology
Pages 717-719
Language en
Subject categories Dermatology and Venereal Diseases


The preservative methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) is a well-known sensitiser and present in the Swedish baseline series since the 1980s. The proportions of MCI/MI are 3:1. MI alone has been used as a preservative since less than 10 years. This study was conducted on behalf of the Swedish Contact Dermatitis Research Group to evaluate inclusion of MI in the Swedish baseline series since the preparation of MCI/MI might fail to detect contact-allergic reactions to MI alone. Patients with suspected allergic contact dermatitis at 5 Swedish dermatology departments were consecutively patch tested with MI 2,000 ppm aq and MCI/MI 200 ppm aq. The number of cases with exclusive contact allergy to MI varied between 0.8-4.2%. In total, 1.9% reacted exclusively to MI and not to MCI/MI. Due to the considerable frequency of contact allergy to MI not traced by MCI/MI, MI 2,000 ppm aq is included in the Swedish baseline series from January 2014. This corresponds to a dose of 60 μg/cm2.

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