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Renal function affects absorbed dose to the kidneys and haematological toxicity during (177)Lu-DOTATATE treatment.

Journal article
Authors Johanna Svensson
Gertrud Berg
Bo Wängberg
Maria Larsson
Eva Forssell-Aronsson
Peter Bernhardt
Published in European journal of nuclear medicine and molecular imaging
Volume 42
Issue 6
Pages 947-955
ISSN 1619-7089
Publication year 2015
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 947-955
Language en
Links dx.doi.org/10.1007/s00259-015-3001-...
Keywords Lu-177-DOTATATE therapy, PRRT, Neuroendocrine tumours, Dosimetry
Subject categories Diagnostic radiology, Kidney diseases

Abstract

Peptide receptor radionuclide therapy (PRRT) has become an important treatment option in the management of advanced neuroendocrine tumours. Long-lasting responses are reported for a majority of treated patients, with good tolerability and a favourable impact on quality of life. The treatment is usually limited by the cumulative absorbed dose to the kidneys, where the radiopharmaceutical is reabsorbed and retained, or by evident haematological toxicity. The aim of this study was to evaluate how renal function affects (1) absorbed dose to the kidneys, and (2) the development of haematological toxicity during PRRT treatment.

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