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The growth hormone receptor exon 3-deleted/full-length polymorphism and response to growth hormone therapy in prepubertal idiopathic short children.

Journal article
Authors Gunnel Hellgren
Camilla A M Glad
B Jonsson
Gudmundur Johannsson
Kerstin Albertsson-Wikland
Published in Growth Hormone & IGF Research
Volume 25
Issue 3
Pages 127-135
ISSN 1096-6374
Publication year 2015
Published at Institute of Neuroscience and Physiology
Institute of Medicine
Institute of Clinical Sciences, Department of Pediatrics
Pages 127-135
Language en
Links dx.doi.org/10.1016/j.ghir.2015.02.0...
Keywords Growth hormone treatment, Prepubertal children, Growth hormone receptor, Exon 3 deletion, Idiopathic short stature
Subject categories Pediatrics

Abstract

The primary aim of the study was to evaluate d3-GHR as a possible cause of increased GH sensitivity in children with delayed infancy-childhood transition (DICT). The secondary aim was to investigate the impact of the GHR exon 3 deleted/full-length (d3/fl) polymorphism on GH treatment response in prepubertal children classified as having idiopathic short stature (ISS).

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