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Gastric fluid cytokines are associated with chorioamnionitis and white blood cell counts in preterm infants.

Journal article
Authors Kristina Bry
Bo Jacobsson
Staffan Nilsson
Published in Acta paediatrica (Oslo, Norway : 1992)
Volume 104
Issue 6
Pages 575-580
ISSN 1651-2227
Publication year 2015
Published at Department of Mathematical Sciences, Mathematical Statistics
Institute of Clinical Sciences, Department of Pediatrics
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 575-580
Language en
Links dx.doi.org/10.1111/apa.12947
Keywords Chorioamnionitis; Cytokines; Inflammation; Preterm birth; White blood cell count
Subject categories Pediatrics

Abstract

AimThe aim of this study was to determine whether the concentration of cytokines in the gastric fluid at birth was associated with chorioamnionitis or funisitis and with the white blood cell counts of very premature newborns.

MethodsWe retrieved gastric fluid from 27 preterm infants with a gestational age of <29weeks within 1h of birth and used enzyme-linked immunosorbent assay to measure the concentrations of interleukin (IL)-1beta, epithelial cell-derived neutrophil-activating peptide (ENA)-78, IL-8 and growth-related oncogene (Gro)-alpha. The presence of histologic chorioamnionitis or funisitis in the placentas and the highest white blood cell count of the infants during the first week of life were compared to the cytokine concentrations.

ResultsGastric fluid concentrations of IL-1beta, ENA-78, IL-8 and Gro-alpha were strongly associated with chorioamnionitis and funisitis. In addition, chorioamnionitis and funisitis and gastric aspirate cytokine levels were associated with the highest white blood cell counts of the infants during the first week of life.

ConclusionThis study suggests that levels of inflammatory cytokines in the gastric fluid of premature infants at birth can be used to assess the exposure of the infants to antenatal inflammation.

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