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Gold and silver nanoparticle-assisted laser desorption ionization mass spectrometry compatible with secondary ion mass spectrometry for lipid analysis

Conference paper
Authors Amir Saeid Mohammadi
John S. Fletcher
Per Malmberg
Andrew G Ewing
Published in Surface and Interface Analysis: 19th International Conference on Secondary Ion Mass Spectrometry (SIMS)
ISSN 0142-2421
Publication year 2014
Published at Department of Chemistry and Molecular Biology
Language en
Links dx.doi.org/10.1002/sia.5609
Keywords LDI mass spectrometry compatible with SIMS; Au Ag nanoparticle LDI; NPs spray-on procedure; IMS lipid analysis; Au and Ag nanoparticles
Subject categories Chemical Engineering, Physical Chemistry

Abstract

To provide a convenient organic matrix-free spray-on sample preparation for laser desorption ionization (LDI) that is compatible with secondary ion mass spectrometry (SIMS) imaging mass spectrometry (IMS) techniques, silver and gold nanoparticles (NPs) were applied on a 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) lipid sample. Application of Ag and Au nanoparticles to the POPC sample allowed POPC lipid fragments to be detected using NP-LDI in both positive and negative polarities. In addition, the same sample prepared for NP-LDI experiments was used for C-60 SIMS lipid analysis, and a secondary ion signal enhancement was obtained for the [M+H](+) ion of the POPC lipid as well as for characteristics POPC lipid fragments in positive ion mode.

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