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Spontaneous colitis in Muc2-deficient mice reflects clinical and cellular features of active ulcerative colitis.

Journal article
Authors Ulf Alexander Wenzel
Maria K Magnusson
Anna Rydström
Caroline Jonstrand
Julia Hengst
Malin E V Johansson
Anna Velcich
Lena Öhman
Hans Strid
Henrik Sjövall
Gunnar C. Hansson
Mary Jo Wick
Published in PloS one
Volume 9
Issue 6
Pages e100217
ISSN 1932-6203
Publication year 2014
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages e100217
Language en
Links dx.doi.org/10.1371/journal.pone.010...
Subject categories Microbiology in the medical area

Abstract

The colonic mucus layer plays a critical role in intestinal homeostasis by limiting contact between luminal bacteria and the mucosal immune system. A defective mucus barrier in animal models allows bacterial contact with the intestinal epithelium and results in spontaneous colitis. A defective mucus barrier is also a key feature of active ulcerative colitis (UC). Alterations in the immune compartment due to intestinal bacterial breach in mice lacking the colon mucus barrier have not been characterized and correlated to active UC.

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