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MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma

Journal article
Authors Maria Eldh
Roger Olofsson Bagge
Cecilia Lässer
Joar Svanvik
Margareta Sjöstrand
Jan Mattsson
Per Lindnér
Dong-Sic Choi
Yong Song Gho
Jan Lötvall
Published in BMC Cancer
Volume 14
Pages 962
ISSN 1471-2407
Publication year 2014
Published at Institute of Clinical Sciences, Department of Surgery
Krefting Research Centre
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 962
Language en
Links dx.doi.org/10.1186/1471-2407-14-962
Keywords Exosomes, Extracellular vesicles, Biomarker microRNA, Uveal melanoma, Liver perfusion
Subject categories Cell and molecular biology, Cancer and Oncology, Surgery

Abstract

Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including malignant melanoma cells. This clinical translational study included patients undergoing isolated hepatic perfusion (IHP) for metastatic uveal melanoma, from whom exosomes were isolated directly from liver perfusates. The objective was to determine whether exosomes are present in the liver circulation, and to ascertain whether these may originate from melanoma cells.

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