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GlycoDigest: a tool for the targeted use of exoglycosidase digestions in glycan structure determination

Journal article
Authors L. Gotz
J. L. Abrahams
J. Mariethoz
P. M. Rudd
Niclas G. Karlsson
N. H. Packer
M. P. Campbell
F. Lisacek
Published in Bioinformatics
Volume 30
Issue 21
Pages 3131-3133
ISSN 1367-4803
Publication year 2014
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 3131-3133
Language en
Links dx.doi.org/10.1093/bioinformatics/b...
Keywords Biochemical Research Methods, Biotechnology & Applied Microbiology, Computer Science, Interdisciplinary Applications, Mathematical &, Computational Biology, Statistics & Probability
Subject categories Cell biology, Bioinformatics (Computational Biology)

Abstract

Sequencing oligosaccharides by exoglycosidases, either sequentially or in an array format, is a powerful tool to unambiguously determine the structure of complex N- and O-link glycans. Here, we introduce GlycoDigest, a tool that simulates exoglycosidase digestion, based on controlled rules acquired from expert knowledge and experimental evidence available in GlycoBase. The tool allows the targeted design of glycosidase enzyme mixtures by allowing researchers to model the action of exoglycosidases, thereby validating and improving the efficiency and accuracy of glycan analysis.

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