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Characterising the toxicology and ecotoxicology of industrial chemicals in Europe

Authors Mikael Gustavsson
Andreas Hellhof
Thomas Backhaus
Published in Poster presentation at the SETAC conference, Basel, Switzerland
Publication year 2014
Published at Department of Biological and Environmental Sciences
Language en
Keywords Hazard Assessment, Industrial Chemicals, REACH, PNEC Distributions
Subject categories Biological Sciences


Industrial chemicals have to be registered in Europe under the REACH Regulation (EC) 1907/2006 if they are put on the European market at more than 1 ton/year. Existing chemicals are phased stepwise into REACH, in May 2013 the deadline for the registration of chemicals in the 100-1000 tons/year band passed. The publicly available database at the European Chemicals Agency (ECHA) lists all currently registered chemicals and currently contains the basic hazard descriptors for 10655 unique substances from 41973 dossiers (Nov. 2013), in the form of PNECs (Predicted No Effect Concentrations) and DNELs (Derived No Effect Levels). In order to characterize the toxicological and ecotoxicological hazard of chemicals in Europe a distribution analysis of these data was performed. They will be presented with a view to answer the following questions: (i) what is the maximum, minimum and average (eco)toxicity of an industrial chemical in Europe?; (ii) is there a difference between the (eco)toxicities of compounds from different production volumes (tonnage bands)?; (iii) do the data allow to identify differences in the sensitivities of the different environmental compartments? (iv) is there a correlation between basic physico-chemcial characteristics (molecular weight, vapour pressure, lipophilicity, etc) and (eco)toxicity? The results from the analysis of industrial chemicals will be contrasted with similar (eco)toxicity distributions of pesticides, priority pollutants from the water framework directive and marine priority pollutants.

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