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Absence of cytomegalovirus in high-coverage DNA sequencing of human glioblastoma multiforme.

Journal article
Authors Ka-Wei Tang
Kristoffer Hellstrand
Erik Larsson
Published in International journal of cancer. Journal international du cancer
Volume 136
Issue 4
Pages 977–981
ISSN 1097-0215
Publication year 2015
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Institute of Biomedicine, Department of Infectious Medicine
Pages 977–981
Language en
Links dx.doi.org/10.1002/ijc.29042
Keywords cytomegalovirus;glioblastoma multiforme;computational biology
Subject categories Molecular medicine (genetics and pathology)

Abstract

Cytomegalovirus (CMV) has been proposed to be associated with glioblastoma multiforme, but there are conflicting results including lack of CMV mRNA in transcriptome sequencing data. Here, we utilized deep-coverage whole-genome sequencing data to detect latent CMV DNA in surgically resected tumors and to assess the relative proportions of viral and human DNA. We did not find traces of CMV in 52.6 billion DNA sequencing reads from 34 glioblastomas. By statistical analysis, we conclude that should the virus be present in these tumors, the average CMV level does not exceed one virus per 240,000 tumor cells (99% CI).

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