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Lower urinary tract symptoms are associated with low levels of serum serotonin, high levels of adiponectin and fasting glucose, and benign prostatic enlargement.

Journal article
Authors Mohammad-Ali Haghsheno
Dan Mellström
Ralph Peeker
Jan Hammarsten
Mattias Lorentzon
Valter Sundh
Magnus Karlsson
Claes Ohlsson
Jan-Erik Damber
Published in Scandinavian journal of urology
Volume 49
Issue 2
Pages 155–161
ISSN 2168-1813
Publication year 2015
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Clinical Sciences, Department of Urology
Centre for Bone and Arthritis Research
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 155–161
Language en
Links dx.doi.org/10.3109/21681805.2014.93...
Keywords benign prostatic enlargement, lower urinary tract symptoms, serotonin, urinary incontinence
Subject categories Urology and Nephrology, Cancer and Oncology

Abstract

Abstract Objective. The aim of this study was to test whether lower urinary tract symptoms (LUTS) and urinary incontinence are associated with the metabolic syndrome (MetS). The association between LUTS and benign prostatic enlargement (BPE) was also investigated. Material and methods. A cross-sectional, representative risk factor analysis of LUTS, as measured by the International Prostate Symptom Score (IPSS), and urinary incontinence was conducted. Among 950 representative individuals, aged 69-81 years, the association between clinical, anthropometric, endocrine, metabolic and inflammatory factors on the one hand, as both major and minor aspects of MetS, and LUTS and urinary incontinence, on the other hand, was analysed. The prostate gland volume was measured in a subgroup of 155 randomly selected individuals and the association between LUTS and BPE was estimated. Results. No significant association was found between LUTS or urinary incontinence and the major aspects of the MetS. However, in a multivariate analysis, serum serotonin showed an independent negative correlation with LUTS and with urinary incontinence while fasting serum glucose and serum adiponectin showed a positive correlation with LUTS. Furthermore, in a subgroup of 155 individuals, the prostate gland volume correlated positively with LUTS. Conclusions. The study did not show an association between LUTS or urinary incontinence and the major components of the MetS. However, serum serotonin showed an independent negative correlation with LUTS and with urinary incontinence while fasting serum glucose and serum adiponectin showed a positive correlation with LUTS. The data confirm the general knowledge that BPE may be one of the causative factors of LUTS.

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