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Characterization of acid and non-acid glycosphingolipids of porcine heart valve cusps as potential immune targets in biological heart valve grafts.

Journal article
Authors Angela Barone
John Benktander
Susann Teneberg
Michael Breimer
Published in Xenotransplantation
Volume 21
Issue 6
Pages 510–522
ISSN 1399-3089
Publication year 2014
Published at Institute of Clinical Sciences, Department of Surgery
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 510–522
Language en
Links dx.doi.org/10.1111/xen.12123
Keywords carbohydrate antigens;glycosphingolipid characterization;immune recognition of bioprosthetic heart valves;mass spectrometry;porcine heart valves
Subject categories Transplantation surgery

Abstract

Although xenotransplantation of vascularized organs/cells has not yet reached the clinic, glutaraldehyde-treated bioprosthetic heart valves (BHV), derived from porcine or bovine tissues, are today used for clinical replacement of diseased heart valves. However, the durability of these valve cusps is limited partly due to the onset of immune responses to the grafts. The xenoantigen-determinant Galα3Gal- and corresponding anti-Gal antibodies have been postulated to in part contribute to BHV damage. However, the presence of other non-Gal carbohydrate antigen determinants as well as the immune response to these non-Gal antigens and the inflammatory response generated by their interaction with the immune system has not been studied. In this study, we have isolated and structurally characterized both non-acid and acid glycosphingolipids from naïve porcine aortic and pulmonary valve cusps.

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