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Neuronal and glia-related biomarkers in cerebrospinal fluid of patients with acute ischemic stroke

Journal article
Authors Clara Hjalmarsson
Maria Bjerke
Björn Andersson
Kaj Blennow
Henrik Zetterberg
N David Åberg
Bob Olsson
Carl Eckerström
Lena Bokemark
Anders Wallin
Published in Journal of Central Nervous System Disease
Volume 19
Issue 6
Pages 51-8
ISSN 1179-5735
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 51-8
Language en
Keywords WML; cerebrospinal fluid; neurodegeneration; stroke
Subject categories Internal medicine


BACKGROUND: Cerebral ischemia promotes morphological reactions of the neurons, astrocytes, oligodendrocytes, and microglia in experimental studies. Our aim was to examine the profile of CSF (cerebrospinal fluid) biomarkers and their relation to stroke severity and degree of white matter lesions (WML). METHODS: A total of 20 patients (mean age 76 years) were included within 5-10 days after acute ischemic stroke (AIS) onset. Stroke severity was assessed using NIHSS (National Institute of Health stroke scale). The age-related white matter changes (ARWMC) scale was used to evaluate the extent of WML on CT-scans. The concentrations of specific CSF biomarkers were analyzed. RESULTS: Patients with AIS had significantly higher levels of NFL (neurofilament, light), T-tau, myelin basic protein (MBP), YKL-40, and glial fibrillary acidic protein (GFAP) compared with controls; T-Tau, MBP, GFAP, and YKL-40 correlated with clinical stroke severity, whereas NFL correlated with severity of WML (tested by Mann-Whitney test). CONCLUSIONS: Several CSF biomarkers increase in AIS, and they correlate to clinical stroke severity. However, only NFL was found to be a marker of degree of WML.

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