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TGF-β isoforms induce EMT independent migration of ovarian cancer cells.

Journal article
Authors Jingfang Gao
Yihong Zhu
Mikael Nilsson
Karin Sundfeldt
Published in Cancer cell international
Volume 14
Issue 1
Pages 72
ISSN 1475-2867
Publication year 2014
Published at Sahlgrenska Cancer Center
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 72
Language en
Links dx.doi.org/10.1186/s12935-014-0072-...
Subject categories Cancer and Oncology, Obstetrics and women's diseases

Abstract

Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cadherin, claudin-3 and claudin-4, commonly decreased in human adenocarcinomas are actually up regulated during ovarian carcinogenesis. In human ovarian cancer TGF-β1 may either suppress or promote tumor progression, but whether other TGF-β isoforms (TGF-β2 and TGF-β3) exert similar effects is not known.

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