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TGF-β isoforms induce EMT independent migration of ovarian cancer cells.

Journal article
Authors Jingfang Gao
Yihong Zhu
Mikael Nilsson
Karin Sundfeldt
Published in Cancer cell international
Volume 14
Issue 1
Pages 72
ISSN 1475-2867
Publication year 2014
Published at Sahlgrenska Cancer Center
Institute of Clinical Sciences, Department of Obstetrics and Gynecology
Pages 72
Language en
Subject categories Cancer and Oncology, Obstetrics and women's diseases


Transforming growth factor beta (TGF-β) plays major roles in tumorigenesis by regulating cell growth, epithelial-to-mesenchymal transition (EMT), migration/invasion and metastasis. The epithelial markers E-cadherin, claudin-3 and claudin-4, commonly decreased in human adenocarcinomas are actually up regulated during ovarian carcinogenesis. In human ovarian cancer TGF-β1 may either suppress or promote tumor progression, but whether other TGF-β isoforms (TGF-β2 and TGF-β3) exert similar effects is not known.

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