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Elevated antibody reactivity to measles virus Ncore protein among patients with multiple sclerosis and their healthy siblings with intrathecal oligoclonal immunoglobulin G production

Journal article
Authors Linn Persson
Sonia Longhi
Johanna Enarsson
Oluf Andersen
Sara Haghighi
Staffan Nilsson
Martin Lagging
Maria Johansson
Tomas Bergström
Published in Journal of Clinical Virology
Volume 61
Issue 1
Pages 107-112
ISSN 1386-6532
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Department of Mathematical Sciences, Mathematical Statistics
Institute of Biomedicine, Department of Infectious Medicine
Pages 107-112
Language en
Links dx.doi.org/10.1016/j.jcv.2014.06.01...
Keywords multipel skleros, MS OCB trait, mässlingvirus, antikroppar, likvor, oligoklonala band
Subject categories Clinical Medicine, Neurology

Abstract

Patients with multiple sclerosis (MS) and their healthy siblings with the MS oligoclonal bands (OCB) trait, (a hyperimmune condition in form of two or more CSF enriched OCBs) harbor in cerebrospinal fluid (CSF) and serum elevated immunoglobulin G (IgG) titers against measles crude whole-cell antigen. The underlying mechanism resulting in the increased IgG antibody reactivity to measles remains unclear. The response may represent specific IgG reactivity to measles antigens or unspecific auto-antibodies targeting cellular components in the crude whole virus antigens commonly used in detection assays.

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