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Increase of sodium channels (nav 1.8 and nav 1.9) in rat dorsal root ganglion neurons exposed to autologous nucleus pulposus.

Journal article
Authors Kazuyuki Watanabe
Karin Larsson
Björn Rydevik
Shin-Ichi Konno
Claes Nordborg
Kjell Olmarker
Published in The open orthopaedics journal
Volume 8
Pages 69-73
ISSN 1874-3250
Publication year 2014
Published at Institute of Biomedicine, Department of Pathology
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Institute of Clinical Sciences, Department of Orthopaedics
Pages 69-73
Language en
Keywords DISC herniation, dorsal root ganglion, rat, sciatica, spine, voltage-gated sodium channel
Subject categories Orthopedics


It has been assumed that nucleus pulposus-induced activation of the dorsal root ganglion (DRG) may be related to an activation of sodium channels in the DRG neurons. In this study we assessed the expression of Nav 1.8 and Nav 1.9 following disc puncture.

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