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Improved statistical analysis of pre- and post-treatment patient-reported outcome measures (PROMs): the applicability of piecewise linear regression splines

Journal article
Authors Meridith E Greene
Ola Rolfson
Göran Garellick
Max Gordon
Szilard Nemes
Published in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation
Volume 24
Issue 3
Pages 567-573
ISSN 1573-2649
Publication year 2015
Published at Institute of Clinical Sciences, Department of Oncology
Institute of Clinical Sciences, Department of Orthopaedics
Pages 567-573
Language en
Links dx.doi.org/10.1007/s11136-014-0808-...
Subject categories Orthopedics

Abstract

Patient-reported health-related quality-of-life (HRQoL) measures such as the EuroQol 5 dimension (EQ-5D) index are commonplace when assessing healthcare providers or efficiency of medical techniques. HRQoL measures are generally bounded, and the magnitude of possible improvement depends on the pre-treatment HRQoL value. This paper aimed to assess and illustrated the possibility of modelling the relationship between pre- and post-treatment HRQoL measures with piecewise linear splines.

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