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High Proportion of CD5(+) B Cells in Infants Predicts Development of Allergic Disease

Journal article
Authors Anna-Carin Lundell
S. Johansen
Ingegerd Adlerberth
Agnes E Wold
Bill Hesselmar
Anna Rudin
Published in Journal of Immunology
Volume 193
Issue 2
Pages 510-518
ISSN 0022-1767
Publication year 2014
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Clinical Sciences, Department of Pediatrics
Institute of Biomedicine, Department of Infectious Medicine
Pages 510-518
Language en
Links dx.doi.org/10.4049/jimmunol.1302990
Keywords SOMATIC HYPERMUTATION, STAPHYLOCOCCUS-AUREUS, REDUCED DIVERSITY, ATOPIC, ECZEMA, HAY-FEVER, ASTHMA, TRANSPLANTATION, IDENTIFICATION, RECONSTITUTION, POPULATION, Immunology, RACHAN DP, 1989, BRITISH MEDICAL JOURNAL, V299, P1259
Subject categories Immunology in the medical area

Abstract

Delayed maturation of the immune system has been proposed to be a risk factor for development of allergy, but B cell maturation in relation to allergic disease has not been examined. B cells lose CD5 and acquire CD27 during maturation from immature via mature/naive to Ig-secreting cells and memory cells. We sought to investigate B cell maturation in relation to development of allergic disease and sensitization in the FARMFLORA birth cohort including 65 Swedish children. Total B cell numbers, proportions of CD5(+) and CD27(+) B cells, and levels of IgM, IgG, IgA, and IgE were measured in blood on repeated occasions from birth to 36 mo of age, and related to allergic disease and sensitization at 18 and 36 mo of age with multivariate discriminant analysis. We also compared the expression of CD24 and CD38 within CD5(+) and CD5(neg) B cells in children and in adults. We found that infants with a high proportion of CD5(+) B cells at birth and at 1 mo of age had an increased risk for having allergic disease at 18 and 36 mo of life. Further, the proportions of CD5(+) B cells at 1 mo of age were inversely correlated with total IgG levels at 18 and 36 mo of age. The majority of the CD5(+) B cells were of a CD24(hi/+)CD38(hi/+) immature/naive phenotype at birth (97%), 7 y of age (95%), and in adults (86%). These results suggest that development of allergic disease is preceded by an immaturity in neonatal B cell phenotype.

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