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Comparing and visualizing titanium implant integration in rat bone using 2D and 3D techniques.

Journal article
Authors Anna Arvidsson
Hamid Sarve
Carina B. Johansson
Published in Journal of biomedical materials research. Part B, Applied biomaterials
Volume 103
Issue 1
Pages 12-20
ISSN 1552-4981
Publication year 2015
Published at Institute of Odontology
Pages 12-20
Language en
Links dx.doi.org/10.1002/jbm.b.33168
Subject categories Biomaterials

Abstract

The aim was to compare the osseointegration of grit-blasted implants with and without a hydrogen fluoride treatment in rat tibia and femur, and to visualize bone formation using state-of-the-art 3D visualization techniques. Grit-blasted implants were inserted in femur and tibia of 10 Sprague-Dawley rats (4 implants/rat). Four weeks after insertion, bone implant samples were retrieved. Selected samples were imaged in 3D using Synchrotron Radiation-based μCT (SRμCT). The 3D data was quantified and visualized using two novel visualization techniques, thread fly-through and 2D unfolding. All samples were processed to cut and ground sections and 2D histomorphometrical comparisons of bone implant contact (BIC), bone area (BA), and mirror image area (MI) were performed. BA values were statistically significantly higher for test implants than controls (p < 0.05), but BIC and MI data did not differ significantly. Thus, the results partly indicate improved bone formation at blasted and hydrogen fluoride treated implants, compared to blasted implants. The 3D analysis was a valuable complement to 2D analysis, facilitating improved visualization. However, further studies are required to evaluate aspects of 3D quantitative techniques, with relation to light microscopy that traditionally is used for osseointegration studies.

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