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Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo-controlled, randomised study

Journal article
Authors S. Zaman
K. Aamir
Stefan Lange
Eva Jennische
S. A. Silfverdal
Lars Å Hanson
Published in Acta Paediatrica
Volume 103
Issue 6
Pages 659-664
ISSN 0803-5253
Publication year 2014
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Microbiology and Immunology
Pages 659-664
Language en
Keywords Antisecretory factor, Developing country, Diarrhoeal disease, Paediatric patients, INFLAMMATORY-BOWEL-DISEASE, PROTEIN, PLASMA, IDENTIFICATION, PERMEATION, CHOLERA, TRIAL, FOOD, Pediatrics, PEDIATRICS
Subject categories Immunology in the medical area


AimWe studied the response to high doses of egg yolk containing antisecretory factor (B221((R)), Salovum((R))) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan. MethodsIn a randomised, placebo-controlled trial, 36 children aged 7 to 60months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum((R)) or placebo groups. Initially, 16 grams of Salovum((R)) or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8g every 5h until recovery. The number and consistency of stools were recorded. ResultsThe two groups were comparable in age, gender, duration of diarrhoea, hydration and nutritional status, although the proportion with watery stools was higher in the Salovum((R)) group (p=0.04). Reduction in the frequency of stools was seen at 7 versus 18h (p<0.0001) and normalising of stool consistency was 10 versus 18h, p<0.03) in the Salovum((R)) and placebo groups. The overall effect was 35 versus 70h in the two groups (p=0.001). No side effects were reported. ConclusionHigh doses of AF in the form of Salovum((R)) effectively and safely reduce childhood diarrhoea of a likely broad aetiology.

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