To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Antisecretory factor effe… - University of Gothenburg, Sweden Till startsida
Sitemap
To content Read more about how we use cookies on gu.se

Antisecretory factor effectively and safely stops childhood diarrhoea: a placebo-controlled, randomised study

Journal article
Authors S. Zaman
K. Aamir
Stefan Lange
Eva Jennische
S. A. Silfverdal
Lars Å Hanson
Published in Acta Paediatrica
Volume 103
Issue 6
Pages 659-664
ISSN 0803-5253
Publication year 2014
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Microbiology and Immunology
Pages 659-664
Language en
Links dx.doi.org/10.1111/apa.12581
Keywords Antisecretory factor, Developing country, Diarrhoeal disease, Paediatric patients, INFLAMMATORY-BOWEL-DISEASE, PROTEIN, PLASMA, IDENTIFICATION, PERMEATION, CHOLERA, TRIAL, FOOD, Pediatrics, PEDIATRICS
Subject categories Immunology in the medical area

Abstract

AimWe studied the response to high doses of egg yolk containing antisecretory factor (B221((R)), Salovum((R))) in young children with acute diarrhoea, presenting to the Children's Hospital, Lahore, Pakistan. MethodsIn a randomised, placebo-controlled trial, 36 children aged 7 to 60months with acute diarrhoea of unknown aetiology, with mild-to-moderate dehydration, were randomised to the Salovum((R)) or placebo groups. Initially, 16 grams of Salovum((R)) or ordinary egg yolk (placebo) mixed in oral rehydration salts was given, followed by 8g every 5h until recovery. The number and consistency of stools were recorded. ResultsThe two groups were comparable in age, gender, duration of diarrhoea, hydration and nutritional status, although the proportion with watery stools was higher in the Salovum((R)) group (p=0.04). Reduction in the frequency of stools was seen at 7 versus 18h (p<0.0001) and normalising of stool consistency was 10 versus 18h, p<0.03) in the Salovum((R)) and placebo groups. The overall effect was 35 versus 70h in the two groups (p=0.001). No side effects were reported. ConclusionHigh doses of AF in the form of Salovum((R)) effectively and safely reduce childhood diarrhoea of a likely broad aetiology.

Page Manager: Webmaster|Last update: 9/11/2012
Share:

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?