To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Osteogenic response of hu… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Osteogenic response of human mesenchymal stem cells to well-defined nanoscale topography in vitro

Journal article
Authors Giuseppe Maria de Peppo
Hossein Agheli
Camilla Karlsson
Karin Ekström
Helena Brisby
Maria Lennerås
Stefan Gustafsson
Peter Sjövall
Anna Johansson
Eva Olsson
J. Lausmaa
Peter Thomsen
S. Petronis
Published in International Journal of Nanomedicine
Volume 9
Issue 1
Pages 2499-2515
ISSN 1176-9114
Publication year 2014
Published at Institute of Clinical Sciences, Department of Biomaterials
Institute of Clinical Sciences, Department of Orthopaedics
Pages 2499-2515
Language en
Keywords colloidal lithography; nanotopography; human mesenchymal stem cells; cell proliferation; osteogenic differentiation; mineralization; implantable materials
Subject categories Biomaterials Science


Background: Patterning medical devices at the nanoscale level enables the manipulation of cell behavior and tissue regeneration, with topographic features recognized as playing a significant role in the osseointegration of implantable devices. Methods: In this study, we assessed the ability of titanium-coated hemisphere-like topographic nanostructures of different sizes (approximately 50, 100, and 200 nm) to influence the morphology, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs). Results: We found that the proliferation and osteogenic differentiation of hMSCs was influenced by the size of the underlying structures, suggesting that size variations in topographic features at the nanoscale level, independently of chemistry, can be exploited to control hMSC behavior in a size-dependent fashion. Conclusion: Our studies demonstrate that colloidal lithography, in combination with coating technologies, can be exploited to investigate the cell response to well defined nanoscale topography and to develop next-generation surfaces that guide tissue regeneration and promote implant integration.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?