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The impact of including spatially longitudinal heterogeneities of vessel oxygen content and vascular fraction in 3D tumor oxygenation models on predicted radiation sensitivity.

Journal article
Authors Jakob Heydorn Lagerlöf
Jon Kindblom
Peter Bernhardt
Published in Medical physics
Volume 41
Issue 4
Pages 044101
ISSN 0094-2405
Publication year 2014
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 044101
Language en
Links dx.doi.org/10.1118/1.4866887
Subject categories Cancer and Oncology, Radiological physics

Abstract

Oxygen distribution models have been used to analyze the influences of oxygen tensions on tissue response after radiotherapy. These distributions are often generated assuming constant oxygen tension in the blood vessels. However, as red blood cells progress through the vessels, oxygen is continuously released into the plasma and the surrounding tissue, resulting in longitudinally varying oxygen levels in the blood vessels. In the present study, the authors investigated whether a tumor oxygenation model that incorporated longitudinally varying oxygen levels would provide different predictions of necrotic fractions and radiosensitivity compared to commonly used models with a constant oxygen pressure.

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