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Adipose Tissue-Derived Human Serum Amyloid A Does Not Affect Atherosclerotic Lesion Area in hSAA(+/) (-/)ApoE(-/-) Mice

Journal article
Authors Sofie Ahlin
Maja Olsson
Anna S K Wilhelmson
Kristina Skålen
Jan Borén
Lena M S Carlsson
Per-Arne Svensson
Kajsa Sjöholm
Published in Plos One
Volume 9
Issue 4
Pages e95468
ISSN 1932-6203
Publication year 2014
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Medicine, Department of Molecular and Clinical Medicine
Pages e95468
Language en
Links dx.doi.org/10.1371/journal.pone.009...
https://gup.ub.gu.se/file/129766
Keywords C-REACTIVE PROTEIN, HIGH-DENSITY-LIPOPROTEIN, CORONARY-ARTERY-DISEASE, ACUTE-PHASE PROTEIN, CHOLESTEROL EFFLUX, MACROPHAGE CHOLESTEROL, UP-REGULATION, INFLAMMATION, CELLS, MECHANISMS
Subject categories Immunology in the medical area

Abstract

Chronically elevated serum levels of serum amyloid A (SAA) are linked to increased risk of cardiovascular disease. However, whether SAA is directly involved in atherosclerosis development is still not known. The aim of this study was to investigate the effects of adipose tissue-derived human SAA on atherosclerosis in mice. hSAA1(+/-) transgenic mice (hSAA1 mice) with a specific expression of human SAA1 in adipose tissue were bred with ApoE-deficient mice. The hSAA1 mice and their wild type (wt) littermates were fed normal chow for 35 weeks. At the end of the experiment, the mice were euthanized and blood, gonadal adipose tissue and aortas were collected. Plasma levels of SAA, cholesterol and triglycerides were measured. Atherosclerotic lesion areas were analyzed in the aortic arch, the thoracic aorta and the abdominal aorta in en face preparations of aorta stained with Sudan IV. The human SAA protein was present in plasma from hSAA1 mice but undetectable in wt mice. Similar plasma levels of cholesterol and triglycerides were observed in hSAA1 mice and their wt controls. There were no differences in atherosclerotic lesion areas in any sections of the aorta in hSAA1 mice compared to wt mice. In conclusion, our data suggest that adipose tissue-derived human SAA does not influence atherosclerosis development in mice.

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