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Stem cell responses to plasma surface modified electrospun polyurethane scaffolds.

Journal article
Authors Carl Zandén
Nina Hellström Erkenstam
Thomas Padel
Julia Wittgenstein
Johan Liu
Hans-Georg Kuhn
Published in Nanomedicine: Nanotechnology, Biology and Medicine
Volume 10
Issue 5
Pages 949–958
ISSN 1549-9634
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Pages 949–958
Language en
Links dx.doi.org/10.1016/j.nano.2014.01.0...
Keywords Stem cell, Polyurethane, Scaffold, Surface modification
Subject categories Neuroscience, Biomaterials Science

Abstract

The topographical effects from functional materials on stem cell behavior are currently of interest in tissue engineering and regenerative medicine. Here we investigate the influence of argon, oxygen, and hydrogen plasma surface modification of electrospun polyurethane fibers on human embryonic stem cell (hESC) and rat postnatal neural stem cell (NSC) responses. The plasma gases were found to induce three combinations of fiber surface functionalities and roughness textures. On randomly oriented fibers, plasma treatments lead to substantially increased hESC attachment and proliferation as compared to native fibers. Argon plasma was found to induce the most optimal combination of surface functionality and roughness for cell expansion. Contact guided migration of cells and alignment of cell processes were observed on aligned fibers. Neuronal differentiation around 5% was found for all samples and was not significantly affected by the induced variations of surface functional group distribution or individual fiber topography.

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