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Signal Regulatory Protein Alpha Is Present in Several Neutrophil Granule Populations and Is Rapidly Mobilized to the Cell Surface to Negatively Fine-Tune Neutrophil Accumulation in Inflammation.

Journal article
Authors Asa Stenberg
Anna Karlsson
Elisabeth Feuk-Lagerstedt
Karin Christenson
Johan Bylund
Anna Oldenborg
Liselotte Vesterlund
Takashi Matozaki
Janove Sehlin
Per-Arne Oldenborg
Published in Journal of Innate Immunity
Volume 6
Issue 4
Pages 553-560
ISSN 1662-811X
Publication year 2014
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 553-560
Language en
Links dx.doi.org/10.1159/000357820
Keywords Neutrophils; Inflammation; Signal regulatory protein alpha; Chemotactic factor; Skin window; Exudate
Subject categories Immunology in the medical area

Abstract

Signal regulatory protein alpha (SIRPα) is a cell surface glycoprotein with inhibitory functions, which may regulate neutrophil transmigration. SIRPα is mobilized to the neutrophil surface from specific granules, gelatinase granules, and secretory vesicles following inflammatory activation in vitro and in vivo. The lack of SIRPα signaling and the ability to upregulate SIRPα to the cell surface promote neutrophil accumulation during inflammation in vivo. © 2014 S. Karger AG, Basel.

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