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Peripherally circulating ghrelin does not mediate alcohol-induced reward and alcohol intake in rodents.

Journal article
Authors Elisabeth Jerlhag
Lisa Ivanoff
Axel Vater
Jörgen Engel
Published in Alcoholism, clinical and experimental research
Volume 38
Issue 4
Pages 959-68
ISSN 1530-0277
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Pharmacology
Pages 959-68
Language en
Links dx.doi.org/10.1111/acer.12337
Keywords Alcohol, Food Intake, Ghrelin, Reward
Subject categories Physiology

Abstract

Development of alcohol dependence, a chronic and relapsing disease, largely depends on the effects of alcohol on the brain reward systems. By elucidating the mechanisms involved in alcohol use disorder, novel treatment strategies may be developed. Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor 1A, acts as an important regulator of energy balance. Recently ghrelin and its receptor were shown to mediate alcohol reward and to control alcohol consumption in rodents. However, the role of central versus peripheral ghrelin for alcohol reward needs to be elucidated.

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