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| Authors |
Susanne Nielsen Lena Björck Johanna Berg Kok Wai Giang Tatiana Zverkova Sandström Kristin Falk Sylvia Määttä Annika Rosengren |
|---|---|
| Published in | BMJ open |
| Volume | 4 |
| Issue | 5 |
| Pages | e004598 |
| ISSN | 2044-6055 |
| Publication year | 2014 |
| Published at |
Institute of Health and Care Sciences Institute of Medicine, Department of Molecular and Clinical Medicine |
| Pages | e004598 |
| Language | en |
| Links |
dx.doi.org/10.1136/bmjopen-2013-004... |
| Subject categories | Cardiovascular medicine |
To examine sex-specific trends in 4-year mortality among young patients with first acute myocardial infarction (AMI), 1987-2006. Results From the first to last 5-year period, the absolute excess risk decreased from 1.38 to 0.50 and 1.53 to 0.59 per 100 person-years among men aged 25–44 and 45–54 years, respectively. Corresponding figures for women were a decrease from 2.26 to 1.17 and from 1.93 to 1.45 per 100 person-years, respectively. Trends for women were non-linear, decreasing to the same extent as those for men until the third period, then increasing. For the last 5-year period, the standardised mortality ratio for young survivors of AMI compared with the general population was 4.34 (95% CI 3.04 to 5.87) and 2.43 (95% CI 2.12 to 2.76) for men aged 25–44 and 45–54 years, respectively, and 13.53 (95% CI 8.36 to 19.93) and 6.42 (95% CI 5.24 to 7.73) for women, respectively. Deaths not associated with cardiovascular causes increased from 21.5% to 44.6% in men and 41.5% to 65.9% in women. Conclusions Young male survivors of AMI have low absolute long-term mortality rates, but these rates remain twofold to fourfold that of the general population. After favourable development until 2001, women now have higher absolute mortality than men and a 6-fold to 14-fold risk of death compared with women in the general population.
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