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Nitric oxide in the oxygenator sweep gas reduces platelet activation during experimental perfusion.

Journal article
Authors Karin Mellgren
L G Friberg
G Mellgren
Thomas Hedner
A Wennmalm
Hans Wadenvik
Published in The Annals of thoracic surgery
Volume 61
Issue 4
Pages 1194-8
ISSN 0003-4975
Publication year 1996
Published at Institute of Internal Medicine, Dept of Medicine
Institute for the Health of Women and Children, Dept of Paediatrics
Institute of Internal Medicine, Dept of Clinical Pharmacology
Pages 1194-8
Language en
Keywords Analysis of Variance, Blood Platelets, chemistry, drug effects, Dose-Response Relationship, Drug, Extracorporeal Membrane Oxygenation, instrumentation, methods, statistics & numerical data, Humans, Nitric Oxide, administration & dosage, Plasma, chemistry, drug effects, Platelet Activation, drug effects, Time Factors
Subject categories Clinical Medicine


Hemorrhage is a major complication experienced in 10% to 35% of neonates treated with extracorporeal life support (ECLS). The increased bleeding tendency is partly due to an ECLS-induced thrombocytopenia and impaired platelet function. In the present study, we evaluated the effect of nitric oxide on the ECLS-induced platelet consumption and activation.

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