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Cytokine release during long-term extracorporeal circulation in an experimental model.

Journal article
Authors Katrin Adrian
Karin Mellgren
Maria Skogby
Lars-Göran Friberg
G Mellgren
Hans Wadenvik
Published in Artificial organs
Volume 22
Issue 10
Pages 859-63
ISSN 0160-564X
Publication year 1998
Published at Department of Linguistics
Institute of Internal Medicine, Dept of Medicine
Institute for the Health of Women and Children, Dept of Paediatrics
Pages 859-63
Language en
Keywords Adult, Anticoagulants, blood, Blood Cell Count, Chemotaxis, Leukocyte, physiology, Critical Illness, Cytokines, blood, Equipment Design, Extracorporeal Circulation, instrumentation, methods, Hemoglobins, analysis, Heparin, blood, Humans, Interleukin-1, blood, Interleukin-6, blood, Interleukin-8, blood, Leukocyte Count, Leukocytes, physiology, Neutrophils, cytology, Oxygenators, Platelet Count, Receptors, Interleukin-1, antagonists & inhibitors, Tumor Necrosis Factor-alpha, analysis
Subject categories Clinical Medicine


The objective of this study was to determine the degree of leukocyte activation, as measured by cytokine release, in circulating blood during experimental extracorporeal circulation. Complete in vitro extracorporeal membrane oxygenation (ECMO) circuits were used, and 9 experiments were performed. Whole blood stored at 37 degrees C was used as the control. Blood samples were withdrawn before the start of perfusion and at 24 h of perfusion. Statistically significant releases of interleukin (IL)-1beta, IL-8, and IL-1 receptor antagonist were observed in the perfusion circuits compared to both the control blood and baseline values. Also, increases in plasma tumor necrosis factor (TNF)alpha and IL-6 were seen after 24 h of perfusion although these changes did not reach statistical significance. These results indicate that extracorporeal circulation induced leukocyte activation and cytokine release. These reactions might, as an additional trauma, deteriorate the situation in an already severely ill patient. A search for methods to counteract this untoward activation seems warranted.

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