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A prospective cohort study investigating an exposure-response relationship among vibration-exposed male workers with numbness of the hands

Journal article
Authors Maria Edlund
L. Burstrom
Lars Gerhardsson
R. Lundstrom
T. Nilsson
Helena Sandén
Mats Hagberg
Published in Scandinavian Journal of Work Environment & Health
Volume 40
Issue 2
Pages 203-209
ISSN 0355-3140
Publication year 2014
Published at Institute of Medicine, Department of Public Health and Community Medicine
Pages 203-209
Language en
Keywords carpal tunnel syndrome, hand-arm vibration, HAV, sensorineural symptom, survival analysis, work, carpal-tunnel-syndrome, arm vibration, transmitted vibration, general-population, forest workers, association, symptoms
Subject categories Community medicine


Objective The aim of this study was to investigate the exposure response relationship of hand-arm vibration (HAY) exposure to neurological symptoms (numbness) of the hand in a cohort of vibration-exposed workers. Methods The baseline cohort comprised 241 office and manual workers with and without exposure to HAY. Numbness (the symptom or event) in the hand was assessed for all subjects at baseline and follow-ups after 5, 10, and 16 years. The workers were stratified into quartiles with no exposure in the first quartile and increasing intensity of exposure in quartiles 2-4 (groups 1-3). Data analysis was performed using survival analysis (time-to-event). Information on cumulative exposure and years of exposure to event was collected via questionnaires. Measurements were performed in accordance with the International Organization for Standardization (ISO) 5349-1. Results The hazard ratio (HR) of risk of event (numbness) differed statistically significantly between the non-exposed group (group 0) and the two higher exposure groups (groups 2 and 3). There was also a significant ratio difference between the lowest exposure group (group 1) and the two higher groups. The ratio for group 1 was 1.77 [95% confidence interval (95% CI) 0.96-3.26] compared with 3.78 (95% CI 2.15-6.62) and 5.31(95% CI 3.06-9.20) for groups 2 and 3, respectively. Conclusion The results suggest a dose response relationship between vibration exposure and numbness of the hands. This underlines the importance of keeping vibration levels low to prevent neurological injury to the hands.

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