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High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

Journal article
Authors Johan F Paulsson
Johnny Ludvigsson
Annelie Carlsson
Rosaura Casas
Gun Forsander
Sten A Ivarsson
Ingrid Kockum
Åke Lernmark
Claude Marcus
Bengt Lindblad
Gunilla T Westermark
Published in PloS one
Volume 9
Issue 3
Pages e93053
ISSN 1932-6203
Publication year 2014
Published at
Pages e93053
Language en
Subject categories Pediatrics

Abstract

Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.

Page Manager: Webmaster|Last update: 9/11/2012
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