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Multivariate evaluation of doxorubicin surface-enhanced Raman spectra.

Journal article
Authors Charlotte Eliasson
Anders Lorén
K V Murty
M Josefson
Mikael Käll
Jonas Abrahamsson
Katarina Abrahamsson
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Volume 57
Issue 9
Pages 1907-15
ISSN 1386-1425
Publication year 2001
Published at Department of Chemistry
Department of Physics (GU)
Institute for the Health of Women and Children, Dept of Paediatrics
Pages 1907-15
Language en
Keywords Animals, Antibiotics, Antineoplastic, blood, chemistry, Cattle, Doxorubicin, blood, chemistry, Multivariate Analysis, Plasma, chemistry, Principal Component Analysis, Signal Processing, Computer-Assisted, Spectrum Analysis, Raman
Subject categories Chemistry


Multivariate evaluation of surface-enhanced Raman spectra of doxorubicin in plasma was performed. In a principal component analysis (PCA) all spectral features were modelled into three principal components. The major variation of the data was shown to be the variation of doxorubicin Raman signal together with the doxorubicin fluorescence, whereas the variation due to plasma was of minor importance. It was also shown that the surface-enhanced Raman scattering (SERS) measurements were independent on such factors as measurement occasion and silver colloids. The presented results show that with some improvements, quantification of doxorubicin directly in plasma could be possible.

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