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GH-receptor derived plasma GH binding protein in rainbow trout : Effects of fasting and a single-meal refeeding

Authors Ingibjörg Einarsdottir
Ningping Gong
Marcus Johansson
Björn Thrandur Björnsson
Published in 7th International Symposium of Fish Endocrinology, Buenos Aires, Argentina, 3-6 September 2012
Volume Program and Abstract Book
Pages 205
Publication year 2012
Published at Department of Biological and Environmental Sciences
Pages 205
Language en
Subject categories Animal physiology


Plasma growth hormone binding proteins (GHBPs) transport circulating growth hormone (GH), function as a GH pool and prevent GH from degradation. In mammals, high-affinity GHBPs are identical to the extracellular domain of the growth hormone receptor (GHR). GHBPs have been demonstrated in fish, but their molecular identity has not been confirmed. To examine a possible GHR origin of plasma GHBPs in rainbow trout, a GHBP radioimmunoassay was established, using antibodies raised against a synthesized peptide sequence of the salmonid GHR extracellular domain, and recombinant proteins for iodination and standards. In order to examine effects of nutritional state on GHBP levels, rainbow trout were fasted for four weeks while a control group was fed to satiation. Then, all fish received a single meal and were sampled 2, 4, 8, 24 and 72 h postprandially. During the 4-week fasting, GHBP levels did not change, while plasma GH levels increased, as has been shown in earlier studies. Following the meal, a transient decrease in both GH and GHBP was seen in the fasted fish, lasting 2 to 4 h. This is the first time plasma GHBP levels have been measured in fish. The data indicate that GHBP and GH levels may be regulated independently or in concert. Supported by EU (Project LIFECYCLE FP7-222719).

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