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Antibacterial activity of pepducins, allosterical modulators of formyl Peptide receptor signaling.

Journal article
Authors Malene Winther
Michael Gabl
Tudor I Oprea
Bodil Jönsson
Francois Boulay
Johan Bylund
Claes Dahlgren
Huamei Forsman
Published in Antimicrobial agents and chemotherapy
Volume 58
Issue 5
Pages 2985-8
ISSN 1098-6596
Publication year 2014
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Institute of Medicine
Institute of Biomedicine, Department of Infectious Medicine
Pages 2985-8
Language en
Links dx.doi.org/10.1128/AAC.02716-13
Subject categories Basic Medicine, Clinical Medicine

Abstract

Pepducins containing a fatty acid linked to an amino acid sequence derived from cytosolic parts of a G-protein-coupled receptor (GPCR) constitute a new group of lipopeptide tools in GPCR studies. Pepducins corresponding to the third intracellular loop of formyl peptide receptor 2 (FPR2) activate human neutrophils, and we show here that, in addition, these allosteric modulators of receptor activity also kill bacteria. The functional dualism of FPR2 pepducins could potentially be explored as a novel class of antibacterial drugs with immunomodulatory properties.

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