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Glucocorticoid receptor function is decreased in neutrophils during endotoxic shock.

Journal article
Authors Maria Bergquist
Pernilla Jirholt
Merja Nurkkala
Christian Rylander
Göran Hedenstierna
Catharina Lindholm
Published in The Journal of infection
Volume 69
Issue 2
Pages 113–122
ISSN 1532-2742
Publication year 2014
Published at Institute of Medicine, Department of Rheumatology and Inflammation Research
Pages 113–122
Language en
Links dx.doi.org/10.1016/j.jinf.2014.03.0...
Keywords Lipopolysaccharide; Endotoxin; Glucocorticoid receptor; Sepsis; Dexamethasone
Subject categories Anesthesiology and Intensive Care

Abstract

It remains unclear whether glucocorticoid treatment can improve the outcome of sepsis. The aim of the present study was to investigate if glucocorticoid receptor (GR) expression and function is impaired in lipopolysaccharide (LPS) induced shock, and whether the time point for start of glucocorticoid treatment affects the outcome.

Page Manager: Webmaster|Last update: 9/11/2012
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