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CSF α-synuclein and UCH-L1 levels in Parkinson's disease and atypical parkinsonian disorders.

Journal article
Authors Stefania Mondello
Radu Constantinescu
Henrik Zetterberg
Ulf Andreasson
Björn Holmberg
Andreas Jeromin
Published in Parkinsonism & related disorders
Volume 20
Issue 4
Pages 382–387
ISSN 1873-5126
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 382–387
Language en
Links dx.doi.org/10.1016/j.parkreldis.201...
Keywords α-Synuclein; UCH-L1; Cerebrospinal fluid; Parkinson's disease; Atypical parkinsonian disorders
Subject categories Neurochemistry

Abstract

There is an unmet need for biomarkers for Parkinson's disease (PD) and atypical parkinsonian disorders (APD). α-Synuclein, linked to the pathogenesis of PD, is a promising biomarker candidate in need of further investigation. The ubiquitin carboxy-terminal hydrolase L1 (UCH-L1), a pivotal component of the ubiquitin proteasome system which seems to be disturbed in PD, may also be involved in the pathogenesis of this disorder.

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