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Luminal matrices: An inside view on organ morphogenesis

Journal article
Authors Stefan Luschnig
Anne Uv
Published in Experimental Cell Research
Volume 321
Issue 1
Pages 64-70
ISSN 0014-4827
Publication year 2014
Published at Institute of Biomedicine, Department of Medical and Clinical Genetics
Pages 64-70
Language en
Links dx.doi.org/10.1016/j.yexcr.2013.09....
Keywords Apical extracellular matrix, Chitin, Lumen, Luminal pressure, Mechanical forces, Organogenesis, Tubulogenesis
Subject categories Cell biology

Abstract

Tubular epithelia come in various shapes and sizes to accommodate the specific needs for transport, excretion and absorption in multicellular organisms. The intestinal tract, glandular organs and conduits for liquids and gases are all lined by a continuous layer of epithelial cells, which form the boundary of the luminal space. Defects in epithelial architecture and lumen dimensions will impair transport and can lead to serious organ malfunctions. Not surprisingly, multiple cellular and molecular mechanisms contribute to the shape of tubular epithelial structures. One intriguing aspect of epithelial organ formation is the highly coordinate behavior of individual cells as they mold the mature lumen. Here, we focus on recent findings, primarily from Drosophila, demonstrating that informative cues can emanate from the developing organ lumen in the form of solid luminal material. The luminal material is produced by the surrounding epithelium and helps to coordinate changes in shape and arrangement of the very same cells, resulting in correct lumen dimensions. © 2013 Elsevier Inc.

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