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TMPRSS2-ERG Expression Predicts Prostate Cancer Survival and Associates with Stromal Biomarkers

Journal article
Authors C. Hagglof
P. Hammarsten
K. Stromvall
L. Egevad
Andreas Josefsson
P. Stattin
T. Granfors
A. Bergh
Published in Plos One
Volume 9
Issue 2
Pages e86824
ISSN 1932-6203
Publication year 2014
Published at Institute of Clinical Sciences, Department of Urology
Pages e86824
Language en
Links dx.doi.org/10.1371/journal.pone.008...
Keywords TRANSCRIPTION FACTOR, ERG EXPRESSION, GLEASON SCORE, GENE FUSIONS, TUMOR-GROWTH, REARRANGEMENT, FIBROBLASTS, PROGRESSION, CELLS, STRATIFICATION
Subject categories Cancer and Oncology, Urology and andrology

Abstract

The TMPRSS2-ERG gene fusion is found in approximately half of all prostate cancers. The functional and prognostic significance of TMPRSS2-ERG is, however, not fully understood. Based on a historical watchful waiting cohort, an association between TMPRSS2-ERG, evaluated as positive immune staining, and shorter survival of prostate cancer patients was identified. Expression of ERG was also associated with clinical markers such as advanced tumor stage, high Gleason score, presence of metastasis and prognostic tumor cell markers such as high Ki67, pEGFR and pAkt. Novel associations between TMPRSS2-ERG and alterations in the tumor stroma, for example, increased vascular density, hyaluronan and PDGFR beta and decreased Caveolin-1, all known to be associated with an aggressive disease, were found. The present study suggests that the TMPRSS2-ERG fusion gene is associated with a more aggressive prostate cancer phenotype, supported by changes in the tumor stroma.

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