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Increased frequency of a new polymorphism in the cell division cycle 2 (cdc2) gene in patients with Alzheimer's disease and frontotemporal dementia.

Journal article
Authors Annica Johansson
H Hampel
F Faltraco
K Buerger
L Minthon
N Bogdanovic
Magnus Sjögren
Henrik Zetterberg
L Forsell
L Lilius
L O Wahlund
Lars Rymo
J A Prince
Kaj Blennow
Published in Neuroscience letters
Volume 340
Issue 1
Pages 69-73
ISSN 0304-3940
Publication year 2003
Published at Institute of Clinical Neurosciences
Institute of Laboratory Medicine, Dept of Clinical Chemistry/Transfusion Medicine
Pages 69-73
Language en
Links dx.doi.org/10.1016/S0304-3940(03)00...
Keywords Aged, Aged, 80 and over, Alzheimer Disease, genetics, Apolipoproteins E, genetics, CDC2 Protein Kinase, genetics, Cell Division, genetics, Dementia, genetics, Female, Gene Frequency, genetics, Genetic Predisposition to Disease, genetics, Humans, Male, Middle Aged, Polymorphism, Genetic, genetics
Subject categories Neurosciences

Abstract

Recent studies show linkage between Alzheimer's disease (AD) and two loci on chromosome 10. The cell division cycle 2 (cdc2) gene is located close to one of the chromosome 10 markers, and is a candidate gene for AD since it is involved in the pathogenesis of AD. We sequenced coding exons and flanking intronic sequences and the promoter region on the cdc2 gene and found three new single nucleotide polymorphisms (SNPs). We analyzed 272 Caucasian AD cases, 160 controls and 70 cases with frontotemporal dementia (FTD) for these SNPs. Homozygosity for one of the SNPs (Ex6+7I/D) was more frequent in both AD and FTD cases than in controls. In the combined tauopathy (AD and FTD) group the odds ratio (OR) was 1.77 (95% CI 1.19-2.63) for the Ex6+7II genotype. Our findings suggest that the Ex6+7I allele is associated with tauopathies, both AD and FTD.

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