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Development of IgG antibodies to Exophiala dermatitidis is associated with inflammatory responses in patients with cystic fibrosis.

Journal article
Authors Nahid Kondori
Anders Lindblad
Christina Welinder-Olsson
Christine Wennerås
Marita Gilljam
Published in Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume 13
Issue 4
Pages 391–399
ISSN 1873-5010
Publication year 2014
Published at Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Institute of Clinical Sciences, Department of Pediatrics
Institute of Biomedicine, Department of Infectious Medicine
Pages 391–399
Language en
Links dx.doi.org/10.1016/j.jcf.2013.12.00...
Keywords Exophiala; Cystic fibrosis; IgG antibodies; Fungal infection
Subject categories Respiratory Medicine and Allergy, Pediatrics

Abstract

The clinical importance of airway colonisation by the fungus Exophiala dermatitidis in patients with cystic fibrosis (CF) is unclear. We have previously shown that E. dermatitidis frequently colonises the airways of patients with CF. The aims of the present study were to determine whether patients who are colonised by E. dermatitidis have detectable fungal antigens in the circulation, develop anti-fungal antibodies, and show signs of inflammation and impaired respiratory function.

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