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Misguided migration of C cell precursors to extra-thyroidal locations related to defective pharyngeal pouch development in Shh deficient mice

Journal article
Authors Jessica Westerlund
Louise Andersson
Therese Carlsson
Henrik Fagman
Mikael Nilsson
Published in Cell & Developmental Biology
Volume 2
Issue 4
Pages 129-138
ISSN 2168-9296
Publication year 2013
Published at Institute of Biomedicine
Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 129-138
Language en
Links dx.doi.org/10.4172/2168-9296.100012...
Keywords thyroid development, Shh, Nkx2.1, Foxa2, calcitonin, genetic fate mapping, Rosa26R, ultimobranchial body, C cells
Subject categories Basic Medicine

Abstract

A possible role of Sonic hedgehog (Shh) in recruitment of C cell precursors to the ultimobranchial body (UB) and embryonic thyroid was investigated in Shh-/- mice. Nkx2.1 and Foxa2 co-expression distinguished UB originating in the fourth pharyngeal pouch from other derivatives of pharyngeal endoderm. In mutants UB formed a single structure that failed to bud and instead of fusing with the midline thyroid primordium adhered to the thymic rudiments. Mature C cells appeared in the UB remnant and ectopically in the thymic parenchyma, foregut endoderm and trachea. Thyroid did not contain C cells except minute numbers close to the tracheal interface. Tracing progeny in Shh-CRE/Rosa26R mice showed the vast majority of both UB and thyroid progenitors derived from Shh negative endoderm, but Shh expressing cells appeared in both thyroid primordia before fusion of the two. The findings indicate that Shh determines the endoderm territory for C cell differentiation and guides the migration of C cell precursors into the thyroid, presumably by regulating the separation of glandular domains in the pharyngeal pouch endoderm. A cell-autonomous role of Shh in thyroid morphogenesis is suggested.

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