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Slc26a3 deficiency is associated with loss of colonic HCO3 (-) secretion, absence of a firm mucus layer, and barrier impairment in mice.

Journal article
Authors Fang Xiao
Qin Yu
Junhua Li
Malin E V Johansson
Anurag Kumar Singh
Weiliang Xia
Brigitte Riederer
Regina Engelhardt
Marshall Montrose
Manoocher Soleimani
De-An Tian
Gang Xu
Gunnar C. Hansson
Ursula Seidler
Published in Acta physiologica (Oxford, England)
Volume 211
Issue 1
Pages 161-175
ISSN 1748-1716
Publication year 2014
Published at Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
Pages 161-175
Language en
Links dx.doi.org/10.1111/apha.12220
Subject categories Basic Medicine

Abstract

DRA (downregulated in adenoma, Slc26a3) is a member of the SLC26 family of anion transporters, which is mutated in congenital chloride diarrhoea (CLD). Besides Cl(-) -rich diarrhoea, CLD patients also have a higher than average incidence of intestinal inflammation. In a search for potential explanations for this clinical finding, we investigated colonic electrolyte transport, the mucus layer, and susceptibility against dextran sodium sulphate (DSS)-induced colitis in Slc26a3(-/-) mice.

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