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Low holotranscobalamin and cobalamins predict incident fractures in elderly men: the MrOS Sweden.

Journal article
Authors Catharina Lewerin
Herman Nilsson-Ehle
Stefan Jacobsson
Helena Johansson
Valter Sundh
M K Karlsson
O Ljunggren
Mattias Lorentzon
J A Kanis
Ulf H Lerner
S R Cummings
Claes Ohlsson
Dan Mellström
Published in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
Volume 25
Issue 1
Pages 131-140
ISSN 1433-2965
Publication year 2014
Published at Institute of Medicine, School of Public Health and Community Medicine
Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine
Centre for Bone and Arthritis Research
Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
Pages 131-140
Language en
Links dx.doi.org/10.1007/s00198-013-2527-...
Keywords Cobalamins, Holotranscobalamin, Homocysteine, Fractures, Men
Subject categories Clinical Medicine, Endocrinology

Abstract

In a population-based study on cobalamin status and incident fractures in elderly men (n = 790) with an average follow-up of 5.9 years, we found that low levels of metabolically active and total cobalamins predict incident fractures, independently of body mass index (BMI), bone mineral density (BMD), plasma total homocysteine (tHcy), and cystatin C.

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