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The influence of disease duration, clinical course, and immunosuppressive therapy on the synthesis of intrathecal oligoclonal IgG bands in multiple sclerosis.

Journal article
Authors Markus Axelsson
Niklas Mattsson
Clas Malmeström
Henrik Zetterberg
Jan Lycke
Published in Journal of Neuroimmunology
Volume 264
Issue 1-2
Pages 100-5
ISSN 0165-5728
Publication year 2013
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
Pages 100-5
Language en
Links dx.doi.org/10.1016/j.jneuroim.2013....
Keywords Multiple sclerosis; Intrathecal IgG; Oligoclonal band (OCB); CXCL13; Mitoxantrone; B-cell
Subject categories Neurochemistry

Abstract

We investigated the impact of disease duration, clinical course and immunosuppressive therapy on intrathecal IgG synthesis in multiple sclerosis (MS). Cerebrospinal fluid (CSF) was obtained twice, 8-10years apart, from 20 MS patients and 26 healthy controls, and from 22 MS patients before and after two years of mitoxantrone treatment. The oligoclonal IgG band patterns changed in 15 patients at long-term follow-up, but were only influenced in 4 patients by mitoxantrone therapy. The CSF B-cell-regulating chemokine CXCL13 correlated with intrathecal IgG production suggesting a B-cell-dependence of intrathecal IgG synthesis in MS.

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