To the top

Page Manager: Webmaster
Last update: 9/11/2012 3:13 PM

Tell a friend about this page
Print version

Clinically isolated syndr… - University of Gothenburg, Sweden Till startsida
To content Read more about how we use cookies on

Clinically isolated syndromes with no further disease activity suggestive of multiple sclerosis at the age of population life expectancy

Journal article
Authors Lenka Novakova
Bengt Skoog
Björn Runmarker
Sven Ekholm
Stefan Winblad
Vera Lisovskaja
Oluf Andersen
Published in Multiple sclerosis journal
Volume 20
Issue 4
Pages 496-500
ISSN 1352-4585
Publication year 2014
Published at Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Department of Mathematical Sciences, Mathematical Statistics
Department of Psychology
Pages 496-500
Language en
Keywords Clinically isolated syndrome; multiple sclerosis; cohort; optic neuritis; neuropsychology; magnetic resonance imaging
Subject categories Clinical Medicine


The proportion of patients with clinically isolated syndrome (CIS) reported to convert to clinically definite multiple sclerosis varied between 30 and 75%. We studied the lifetime probability of remaining in the "CIS only" condition. The study was based on the longitudinally followed Gothenburg 1950-1964 incidence cohort (n = 306). Survival analysis revealed that 17.8% of 236 attack onset patients remained "CIS only". Patients with afferent (optic and sensory) symptoms had a better prognosis with approximately 30% of these patients remaining "CIS only". Patients who had experienced no relapse during the first 25 years remained "CIS only" for the subsequent 25 years of follow-up.

Page Manager: Webmaster|Last update: 9/11/2012

The University of Gothenburg uses cookies to provide you with the best possible user experience. By continuing on this website, you approve of our use of cookies.  What are cookies?