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A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27(-)IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation.

Journal article
Authors Mats Bemark
Linda Friskopp
Shanie Saghafian-Hedengren
Susanne Koethe
Anders Fasth
Jonas Abrahamsson
Eva Sverremark-Ekström
Bengt A. Andersson
Karin Mellgren
Published in Clinical immunology (Orlando, Fla.)
Volume 149
Issue 3PB
Pages 421-431
ISSN 1521-7035
Publication year 2013
Published at Institute of Biomedicine, Department of Microbiology and Immunology
Institute of Clinical Sciences, Department of Pediatrics
Pages 421-431
Language en
Links dx.doi.org/10.1016/j.clim.2013.08.0...
Keywords Hematopoietic stem cell transplantation; B cell; Lymphocyte development; Immunological ontogeny
Subject categories Immunology in the medical area, Pediatrics

Abstract

The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27(+) B cells formed after transplantation with the number of CD27(+)IgM(high) cells more affected than class-switched ones. A previously unacknowledged population of CD27(-)IgM(high) cells made up the majority of B cells and this population was also enlarged in healthy children compared to adults. Only a minority of these CD27(-)IgM(high) B cells expressed markers typical for transitional B cells, and the non-transitional CD27(-)IgM(high) cells could be further divided into subpopulations based on their ability to extrude the dye Rhodamine 123 and their expression of CD45RB(MEM55), a glycosylation-dependent epitope. Thus, we define several novel human CD27(-)IgM(high) B cell subpopulations in blood, all of which are present in higher frequencies and numbers in young children and after HSCT than in adults.

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