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Loss of 5-Hydroxymethylcytosine and TET2 in Oral Squamous Cell Carcinoma.

Journal article
Authors Fredrik Jäwert
Bengt Hasséus
Göran Kjeller
Bengt Magnusson
Lars Sand
Lena Larsson
Published in Anticancer research
Volume 33
Issue 10
Pages 4325-8
ISSN 1791-7530
Publication year 2013
Published at Institute of Odontology
Pages 4325-8
Language en
Links www.ncbi.nlm.nih.gov/entrez/query.f...
Subject categories Cancer and Oncology, Dentistry, Otorhinolaryngology

Abstract

Aim: Epigenetic modifications, such as DNA methylation, are considered important in the regulation of target genes in cancer development. 5-Hydroxymethylcytosine (5hmC) was recently discovered to be related to the process of malignant transformation. The influence of DNA methylation in oral squamous cell carcinomas (OSCC) is not fully-understood. Therefore, the aim of the present study was to investigate the DNA methylation pattern in OSCC compared to healthy oral epithelium.

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