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Numerical modeling of susceptibility-related MR signal dephasing with vessel size measurement: Phantom validation at 3T.

Journal article
Authors Nicolas A Pannetier
Maja Sohlin
Thomas Christen
Lothar Schad
Norbert Schuff
Published in Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume 72
Issue 3
Pages 646–658
ISSN 1522-2594
Publication year 2014
Published at Institute of Clinical Sciences, Department of Radiation Physics
Pages 646–658
Language en
Links dx.doi.org/10.1002/mrm.24968
Keywords quantitative BOLD;vessel size measurement;diffusion;magnetic susceptibility;MR numerical model
Subject categories Radiological physics

Abstract

MRI is used to obtain quantitative oxygenation and blood volume information from the susceptibility-related MR signal dephasing induced by blood vessels. However, analytical models that fit the MR signal are usually not accurate over the range of small blood vessels. Moreover, recent studies have demonstrated limitations in the simultaneous assessment of oxygenation and blood volume. In this study, a multiparametric MRI framework that aims to measure vessel radii in addition to magnetic susceptibility and volume fraction was introduced.

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